TruSight Lymphoma 40

Expert-defined panel targeting somatic mutations associated with lymphomas.Read More...
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TruSight Lymphoma 40 (8 samples)

20015966

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TruSight Lymphoma 40 (48 samples)

20015967

Price
 
 
Accessory Products

TruSeq FFPE DNA Library Prep QC Kit (24 samples)

FC-121-9999

Price
 
 

TruSeq Custom Amplicon Index Kit (96 indexes, 384 samples)

FC-130-1003

Price
 
 

Product Highlights

TruSight Lymphoma 40 uses expert-defined content and proven next-generation sequencing (NGS) technology to identify somatic variants associated with lymphomas.

The panel content was designed by a consortium of recognized lymphoma experts with input from industry guidelines1,2 and relevant literature.3 The panel targets genes frequently mutated in lymphomas, including:

  • Classical Hodgkin lymphoma
  • Diffuse large B cell lymphoma
  • Chronic lymphocytic leukemia
  • Hairy cell leukemia
  • Waldenstrom’s macroglobulinemia

TruSight Lymphoma 40 covers 9 fullgenes (exons only) and exonic hotspots on 31 additional genes, providing a comprehensive assessment of key genes known to be associated with lymphomas in a single test. The result is an accurate, cost-effective solution that enables researchers to profile this class of hematological malignancies.

View the gene list

TruSight Lymphoma 40 libraries are ideally suited to run on the MiSeq System. Sequence data generated from TruSight Lymphoma 40 libraries are analyzed using on-instrument MiSeqReporter software or the Amplicon DS BaseSpace App. Filtering and annotation can then be performed using BaseSpace Variant Interpreter or Variant StudioSoftware.

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Specifications

Method-Specific Workflow Example

 
TruSight Lymphoma 40 Gene List
ATM CD79B ID3 NOTCH1 RRAGC TNFAIP3
B2M CIITA IDH2 NOTCH2 SF3B1 TNFRSF14
BIRC3 CREBBP JAK3 PLCG1 SOCS1 TP53
BRAF CXCR4 (CD184) KLF2 PLCG2 STAT3 TRAF3
BTK EGR2 MAP2K1 POT1 STAT5B XPO1
CARD11 EZH2 MYD88 RHOA TCF3  
CD79A GNA13 NFKBIE RPS15 TET2  

Product Literature

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Manuals and Support Information

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References
  1. National Comprehensive Cancer Network. NCCN Clinical Practice Guidelines in Clinical Oncology. https://www.nccn.org/professionals/physician_gls/f_guidelines.asp#site. Accessed September 30, 2017.
  2. European Research Initiative on CLL. ERIC Guidelines. http://www.ericll.org/pages/ericguidelines. Accessed October 5, 2017.
  3. Mata E, Díaz-López A, Martín-Moreno AM, et al. Analysis of the genomic heterogeneity in Hodgkin lymphoma using next generation sequencing. Blood. 2015;126(23):178.