Complex Diseases: The Connection Between Genomic Variability and the Expression of a Phenotype

25 July 2016

The connection between genomic variability and the expression of a phenotype is often complex. Furthermore, in genetics, we often think about DNA sequences and RNA expression levels. However, many complex as well as Mendelian diseases are caused by the accumulation of misfolded proteins, and a clear correlation between DNA, RNA, and protein folding is sometimes missing.

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Publication Links:
PMID: 26998692 | Dooley, et al. (2016): ncbi.nlm.nih.gov/pubmed 26998692
PMID: 27065010 | Chen, et al. (2016): ncbi.nlm.nih.gov/pubmed 27065010

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