Human microbiome analysis is the study of microbial communities found in and on the human body. The goal of human microbiome studies is to understand the role of microbes in health and disease.
Traditionally, studying samples from human skin, stool, or blood relied on time- and labor-intensive microbiology techniques of growing and isolating individual organisms followed by phenotypic or genotypic analysis. Microbial community profiling within a single sample was not possible with these methods.
The advent of next-generation sequencing (NGS) enabled several high-profile collaborative projects including the Human Microbiome Project and MetaHIT, which have published a wide range of data on the human microbiome using NGS as a foundational tool.
The throughput and cost savings of NGS have fueled metagenomics studies capable of surveying the genomes of entire communities, including those of unculturable organisms.
The Ribo-Zero Plus rRNA Depletion Kit removes rRNA before RNA-Seq, enabling you to focus on high-value portions of the transcriptome. This technical note demonstrates rRNA depletion performance on microbial isolate and community samples, while comparing against previous kit versions.Read Technical Note
The MiSeq System is enabling the Saca la Lengua project research team to sequence thousands of samples to identify the variety of bacteria and fungi that live in the human mouth.Read Interview
Researchers at Microba are investigating the genomes of microbes to improve our understanding of human health, disease, and microbial evolution.Read Interview
Dental calculus, the hard deposit the dentist scrapes off your teeth, is the only part of your body that fossilizes during your lifetime.View Video
A comprehensive workflow for NGS-based microbiome profiling delivers enhanced insights for metagenomics studies.Read Article
Microbial communities can influence host immune response, affecting cancer progression and treatment efficacy. As NGS-based research continues to explore host–microbiome interactions, there is hope that information about the human microbiome might inform immunotherapeutic strategies.Learn More