With the Infinium MethylationEPIC BeadChip Kit, researchers can interrogate over 850,000 methylation sites quantitatively across the genome at single-nucleotide resolution. Multiple samples, including FFPE, can be analyzed in parallel to deliver high-throughput power while minimizing the cost per sample.
Infinium HD array technology enables content selection independent of bias-associated limitations often associated with methylated DNA capture methods. The result is a pan-enhancer and coding region view of the methylome that can be used for epigenome-wide association studies on a variety of human tissues.
This kit includes content categories requested by methylation experts, such as:
MethylationEPIC data analysis is supported by the GenomeStudio Methylation Module. GenomeStudio Software enables researchers to effortlessly perform differential methylation analysis for small-scale studies. It features advanced visualization tools that enable researchers to view vast amounts of data in a single graph, such as heat maps, scatter plots, and line plots.
These tools and the GenomeStudio Genome Browser display valuable information such as chromosomal coordinates, percent GC, location in a CpG Island, and methylation β values.
For large-scale studies, there are many free analysis packages that work in the software framework R for normalization, and differential analysis of methylation data. Instructional videos explain the use of these data analysis packages.
Technical Note | PDF 1 MB
Custom Cluster File Creation for Improved Copy Number Analysis
Technical Note | PDF < 1 MB
Analyzing FFPE Samples with Infinium Microarrays
Technical Note | PDF < 1 MB
Technical Note | PDF < 1 MB
STM Reagent Improves Robustness of Infinium Methylation Assay
Technical Note | PDF < 1 MB
Infinium Methylation BeadChip Application Note
Application Note | PDF < 1 MB
Automation of Illumina TruSeq Exome Enrichment Using the Agilent Bravo Liquid Handling Platform
Application Note | PDF < 1 MB
Infinium MethylationEPIC BeadChip
Data Sheet | PDF 1 MB
The Infinium MethylationEPIC Kit is the recommended replacement product for the HumanMethylation450 BeadChip Kit, which has been discontinued. Illumina remains committed to providing you with high-quality support and service.