Informatics products

Illumina Connected Insights

Streamline precision oncology with Illumina Connected Insights

Comprehensive insights and automation to support somatic oncology variant interpretation and reporting for any assay, at any scale

Precision-engineered variant interpretation and reporting for oncology

Illumina Connected Insights is a powerful software enabling AI-assisted variant interpretation and reporting of next-generation sequencing (NGS) data.  Harnessing globally-recognized knowledge sources and ingesting data from a wide range of oncology assays, Connected Insights is precision-engineered to enhance accuracy of results and accelerate reporting.

Streamlined

Unify your knowledge sources in one powerful solution and streamline interpretation with customizable automation. Reduce your variant review lists by up to 90%*.

Integrated

Remove unnecessary touchpoints and move from sequencing through draft report faster. Seamless compatibility with Illumina assays, instruments, and software, including DRAGEN secondary analysis—winner of the FDA Truth Challenge.

Powered for growth

Keep pace with the latest science and future-proof your lab. Ingest data from any assay, at any scale. Access the latest innovations in variant calling, Illumina proprietary AI algorithms, and visualizations.

Connected Insights Report

We help you achieve

Powerful insights

Generate insights from 55+ knowledge sources including the Clinical Knowledgebase (CKB) from Genomenon, CiVIC, and OncoKB. Prioritize relevant clinical trials, drug labels, and guidelines within a single environment.

Interactive visualizations

Generate gene- and exon-level visualizations for DNA and RNA, variant QC, genome plots for structural variants,  Circos plots, B-allele ratio, fusion plots, and more.

Automation

From data upload, automated guidelines-based oncogenicity classification, to report generation – configure your settings and automate for a streamlined experience with minimum touchpoints.

Future-proofing

Evolve with confidence across assays and applications—from panels to genomes and transcriptomes, from tissue to liquid biopsy and heme.

Regionality

Configure regional content, preferences and language to meet regional needs.

Security

Employ security-first infrastructure and conform to privacy and compliance software requirements and regulations.

Key applications

DNA variants

Identify key DNA variant types (SVs, MNVs, exon-level CNVs, indels, fusions, tandem repeats, LOH) relevant in multiple disease types and across a variety of NGS assays.

RNA variants

Analyze variants from RNA or transcriptomics (fusions, splice variants, and soon expression levels) to gain a deeper and more comprehensive understanding of malignancies.

Biomarker signatures

Uncover more insights by interpreting genome- wide pan-cancer biomarker signatures (TMB, MSI, HRD) with increasing relevance to precision medicine.

Software preview

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Powerful visualizations

Deepen your insights with cutting-edge visualizations –explore genome view, DNA and RNA coverage plots, variant allele frequency (VAF), fusion plots, and more. 

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Automated oncogenicity prediction

Leverage proprietary Illumina AI algorithms and pull from a comprehensive set of sources (including previously curated variants) as predictors to automatically calculate the oncogenicity classification score of relevant variants. 

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Heme Subtype Autoclassification

Automatically detect hematological cancer subtypes based on key guidelines, leveraging interactive evidence maps and automated report summaries.

NGS workflow with Illumina Connected Insights

1
Prep

Prepare libraries for somatic oncology panels, CGP, or other compatible applications.

2
Sequence

Sequence libraries using any Illumina or other sequencing platform.

3
Analyze

Call variants with DRAGEN or other secondary analysis tools to generate VCF (Variant Call Format) output.

4
Interpret

Ingest VCF files to Connected Insights to enable generation of insights and case reporting.

ebook unlock insights with NGS

Unlock insights with NGS tertiary analysis software

Tertiary analysis software can help address the bottleneck for somatic oncology variant interpretation. Learn key considerations and best practices for implementing a streamlined workflow.

Flexible deployment options

Variant interpretation within a secure cloud ecosystem

Directly integrated within the Illumina Connected Software ecosystem,  Connected Insights on the cloud unifies highly scalable data management and processing with  an enterprise-level data privacy and security all within a single environment.  A direct integration option with DRAGEN for variant calling is seamless and automated. 

connected insights dragen cloud

Variant interpretation on-premises

Accessed via a DRAGEN server, Connected Insights-Local supports customers in environments where access to the cloud is not an option. Connected Insights on-premises allows users to directly pair DRAGEN secondary analysis with Connected Insights, offering a solution for local somatic oncology variant calling and interpretation. 

Read about the joint power of DRAGEN and Connected Insights-Local:

connected insights dragen on-premise

High standards of data privacy and protection

To meet the most stringent security requirements, Illumina Connected Insights platform is built with security and compliance at its core. Read the security brief for more details.

Product content and related resources

Illumina Connected Insights data sheet

Read how Connected Insights streamlines, integrates, and powers molecular laboratories for scale and growth.

Connected Insights data sheet

Connected Insights video

Watch this video to understand how you can connect various knowledge sources to streamline data interpretation operations for critical insights.

Connected Insights brochure

Discover how Connected Insights can streamline user-defined variant interpretation research workflows and reduce to research report, all within a single environment.

Download brochure

Connected Insights security brief

Learn how Connected Insights employs key security and privacy features to protect sensitive NGS data. 

View security brief

Illumina informatics for oncology

Find out more about how Illumina informatics enables the most accurate and comprehensive workflow on the market for oncology NGS.

View website

The Jackson Laboratory advances precision medicine with an end-to-end workflow

he Jackson Laboratory scales their genetic discovery and molecular profiling services for cancer neurogenomics, adopting Illumina Connected Insights as part of an end-to-end Illumina informatics workflow.

Read story

Connected Insights podcast

Jing Gao, VP of Illumina Informatics, speaks to Illumina’s vision for oncology informatics.

Listen to podcast

Updates: hear the latest

View the software resources page for the latest release information and other news.

View software resources

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Whole-exome sequencing

Focus on sequencing coding regions, which frequently contain mutations that affect tumor progression, for a cost-effective approach.

Whole-genome sequencing

Get a genome-wide view of somatic mutations and other genomic alterations present in cancer tissue and discover novel cancer-associated variants.

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Illumina Connected Analytics ordering

Operationalize informatics and drive scientific insights with Illumina Connected Analytics. Contact us for information on pricing, subscriptions, and more.

TruSight Oncology 500 v2

Enable CGP with a large pan-cancer panel covering all main variant classes plus key biomarkers (TMB, MSI, and HRD) from FFPE tissue.

Ready to connect with a genomic scientist?

Discuss your workflow to learn how you can streamline your NGS operations and power your lab for growth using Illumina Connected Insights.

References

  1. Precision FDA Truth Challenge v2 https://precision.fda.gov/challenges/10