In this video, you will see why muscle loss in pancreatic cancer is far more complex than previously understood. Using PIPseq single-nucleus RNA sequencing from Illumina, researchers mapped transcriptional changes across individual muscle nuclei and uncovered distinct nuclear states, loss of key differentiation regulators, and a cachexia‑specific subpopulation present only during cancer‑induced muscle wasting. Learn how PIPseq is helping define the molecular events that drive cachexia and how these findings bring the field closer to identifying effective therapeutic strategies. Learn more about PIPseq single-cell RNA sequencing: https://www.illumina.com/techniques/sequencing/rna-sequencing/ultra-low-input-single-cell-rna-seq/pip-seq-chemistry.html Learn more about Illumina Single Cell 3' RNA Prep: https://www.illumina.com/products/by-type/sequencing-kits/library-prep-kits/single-cell-rna-prep.html Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc A global genomics leader, Illumina provides comprehensive next-generation sequencing solutions to the research, clinical, and applied markets. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond. View customer spotlight videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79 View Illumina webinars https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ View Illumina support videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWb-JOnusJfYvM LinkedIn: https://www.linkedin.com/company/illumina X: https://x.com/illumina Instagram: https://www.instagram.com/illuminainc/ Facebook: https://www.facebook.com/illuminainc TikTok: https://www.tiktok.com/@illuminainc #geneexpression #singlecell #illumina #pancreaticcancer