Eliminate FFPE noise with machine learning (ML). DRAGEN v4.5 introduces ML-driven somatic variant calling that reduces SNV false positives by 93% in FFPE benchmarks, with 5–20% lower FP+FN overall and superior analytical sensitivity at low variant allele frequencies. ML-based SQ score recalibration enhances signal detection and eliminates strict hard filters — all with no significant increase in runtime. This video is a clip from the full DRAGEN v4.5 webinar, DRAGEN v4.5 - Expanding Accurate Variant Discovery Across the Entire Genome. Watch the full on-demand session here: https://www.illumina.com/events/webinar/2026/dragen-v4.5.html 🔬 Try DRAGEN for free: https://www.illumina.com/destination/dragen-demo.html Subscribe to the Illumina video channel http://www.youtube.com/subscription_center?add_user=IlluminaInc A global genomics leader, Illumina provides comprehensive next-generation sequencing solutions to the research, clinical, and applied markets. Through collaborative innovation, Illumina is fueling groundbreaking advancements in oncology, reproductive health, genetic disease, microbiology, agriculture, forensic science, and beyond. View customer spotlight videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajfheLzgbI4S7xBn7IDbt79 View Illumina webinars https://www.youtube.com/playlist?list=PLKRu7cmBQlahpXlnrrXlQw9itVJ8yHwUZ View Illumina support videos https://www.youtube.com/playlist?list=PLKRu7cmBQlajbm2KGsICWb-JOnusJfYvM LinkedIn: https://www.linkedin.com/company/illumina X: https://x.com/illumina Instagram: https://www.instagram.com/illuminainc/ Facebook: https://www.facebook.com/illuminainc TikTok: https://www.tiktok.com/@illuminainc #Illumina #DRAGEN #FFPE #somaticvariants #machinelearning #oncology #bioinformatics #genomics #cancerresearch For Research Use Only. Not for use in diagnostic procedures.