Frontiers is back, and Illumina is proud to be the title sponsor. This hybrid event will take place April 19–20, 2023, in lovely La Jolla, California, with a view of the Pacific Ocean. Attendees will enjoy two full days of learning about the latest in using rapid whole-genome sequencing for saving critically ill infants and the promise of genomic sequencing in newborn screening. This year’s theme is “Taking Steps Towards Ending the Diagnostic Odyssey.”