DRAGEN-GATK Best Practices: A Deep Dive into Genomic Analysis Pipeline Improvements

The Broad Institute and Illumina have partnered to co-develop and improve upon genomic analysis pipelines, starting with integrating methods from Illumina’s DRAGEN (Dynamic Read Analysis for GENomics) hardware-accelerated informatics platform into the Broad Institute’s GATK (Genomic Analysis ToolKit) Best Practices small variant pipeline, resulting in DRAGEN-GATK Best Practices.

In this webinar, Eric Banks of the Broad Institute will describe some of the issues the development team encountered as it investigated the differences between DRAGEN and GATK tools, highlighting the improvements to methods implemented in the new Best Practices pipeline.

He will also explain how the team assessed functional equivalency between the open source and licensed (hardware-accelerated) version of the pipeline, showing results between the two methods on the same source input.

Speakers:

Eric Banks, Ph.D.
Computational Biologist and Senior Director of the Data Sciences Platform, Institute Scientist
Broad Institute

Severine Catreux, Ph.D
Director of Bioinformatics
Illumina