Spatiotemporal analysis of cardiac tissue during myocardial infarction

10x Genomics and Illumina are excited to co-host a webinar featuring William Boisvert and Jonathan Yap from the University of Hawaii on spatiotemporal analysis of transcriptome-wide changes in cardiac tissue during early onsetof acute myocardial infarction (AMI).

AMI is the leading cause of mortality among cardiovascular diseases. As a result of vascular occlusion throughstenosis or thrombosis, AMI is most often the terminal effect of atherosclerotic plaque formation. The earlystages of AMI exhibit a phasic nature following reperfusion. In this study, the Boisvert Lab uses anischemia/reperfusion mouse model of myocardial infarction, measuring transcriptome-wide, spatio-temporalchanges with the 10x Genomics Visium platform and ingenuity pathway analysis.

The Boisvert Lab's work provides critical insight into transcriptional changes that occur in different regionsduring early-onset AMI. It also shows that, over time, the transcriptional profile throughout the infarcted tissuechanges in accordance with cell behaviors associated with the different phases of AMI. These discoveries offernot only a novel understanding of important genes in AMI with morphological context, but prospectivetherapeutic directions as well.

William Boisvert, PhD
Professor of Medicine
University of Hawaii

For the past 25 years, Dr. Boisvert has been researching various aspects of vascular biology, especially atherosclerosis, focusing on the field ofimmunology to investigate the inflammatory aspects of atherosclerosis. His most recent projects include cardiovascular diseases in HIV-infected individuals and the role of macrophages in post-myocardial infarction cardiac remodeling.

Jonathan Yap, PhD
Postdoctoral Fellow
University of Hawaii

Dr. Yap earned a MS degree in physiology and a PhD in cell and molecular biology from the University of Hawaii at Manoa. In 2020, he began his postdoctoral work and currently conducts research as a research fellow in William Boisvert’s lab at the Hawaii Center for Cardiovascular Research.