Sleeping Sickness: Unveiling the trickster | Illumina SciMon Video

1 December 2014

Due to the poor safety and efficacy of current drugs, new treatments for African trypanosomiasis are required. Sleeping sickness is caused by the parasite, trypanosome brucei that can cross the blood-brain barrier, leading to morbidity and death if untreated. Sequencing is currently being used to study chemicals that can force the parasite into a non-transmissible form, as a way to prevent transmission. By understanding the life cycle of the parasite, ways in which it evades the immune system and novel guide RNAs may help us develop more effective drugs. For more information on applications of Illumina technology in the field of Microbial Genomics, please visit us at Illumina: Microbial Genomics Products: HiSeq: Publication Links: PMID: 24442893 | MacGregor P., et al. (2014): PMID: 24731931 | Manna P.T., et al. (2014): PMID: 24174546 | Koslowsky D., et al. (2014): Publication Research Reviews: Virus Detection and Research: Metagenomics 2nd Edition: The Science Mondays (SciMon) series is brought to you by Illumina Illumina hosts Swati Kadam, Ph.D., Scientific Liaison, Scientific Affairs and Jacques Retief, Associate Director Scientific Affairs deliver 5 minutes of scientific enlightenment on the latest discoveries. Keywords: Small RNA, RNA sequencing, Sleeping sickness, Trypanosoma brucei, tsetse fly, glycoprotein, cell surface, guide RNA, parasite, African trypanosomiasis, drugs, transmission, immune system, variable surface glycoprotein, Illumina,

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