NovaSeq 6000Dx Instrument

The Future of Clinical Genomics is Here

Welcome to a new era for clinical labs. The NovaSeq 6000Dx is our first IVD-compliant high-throughput sequencing instrument for the clinical lab. Push the boundaries of clinical genomics with scalable throughput and improved economics like never before.

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The Future of Clinical Genomics is Here

Welcome to a new era for clinical labs. The NovaSeq 6000Dx is the first IVD-compliant high-throughput sequencing instrument for the clinical lab. Push the boundaries of clinical genomics with scalable throughput and improved economics like never before.

Speak to a Specialist

See the Instrument

NovaSeq 6000DX

Conduct in vitro diagnostics and clinical research on a single instrument

The NovaSeq 6000Dx features dual modes for IVD and RUO applications, opening new possibilities across a range of sample types, sequencing methods, and clinical research applications.

Conduct in vitro diagnostics and Clinical Research on a single instrument

The NovaSeq 6000Dx features dual modes for IVD and RUO applications, opening new possibilities across a range of sample types, sequencing methods, and clinical research applications.

Integrated data analysis with DRAGEN

The NovaSeq 6000Dx system includes a DRAGEN Server paired with the sequencer, enabling streamlined and accurate data analysis. The intuitive software interface makes it easy to maximize your analysis efficiency.

Integrated data analysis with DRAGEN

The NovaSeq 6000Dx system includes a DRAGEN Server paired with the sequencer, enabling streamlined and accurate data analysis. The intuitive software interface makes it easy to maximize your analysis efficiency.

Intuitive, streamlined user interface

Plan and stagger your sequencing runs and analysis using Illumina Run Manager. Monitor run progress, control instrument, and user management from the instrument or remotely. Illumina Run Manager also helps ensure data security and privacy.

Intuitive, streamlined user interface

Plan and stagger your sequencing runs and analysis using Illumina Run Manager. Monitor run progress, control instrument, and user management from the instrument or remotely. Illumina Run Manager also helps ensure data security and privacy.

Flexible Targeted Sequencing
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Flexible targeted sequencing

NovaSeq 6000Dx is compatible with Illumina DNA Prep with Enrichment Dx, a rapid library preparation and enrichment solution that works with fixed and custom panels for increased flexibility. Combined with the integrated DRAGEN for Illumina DNA Prep with Enrichment Dx App, the NovaSeq 6000Dx enables a high-throughput clinical testing workflow.

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Flexible Targeted Sequencing

Flexible targeted sequencing

NovaSeq 6000Dx is compatible with Illumina DNA Prep with Enrichment Dx, a rapid library preparation and enrichment solution that works with fixed and custom panels for increased flexibility. Combined with the integrated DRAGEN for Illumina DNA Prep with Enrichment Dx App, the Novaseq 6000Dx enables a high-throughput clinical testing workflow.

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Flexible for a variety of applications

From an integrated, unified interface, users can easily switch between RUO and IVD modes to run the NovaSeq 6000Dx instrument, offering the flexibility to perform IVD testing, translational development, and clinical research on a single platform.

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Compare with NextSeq 550Dx & NovaSeq 6000

  NovaSeq 6000Dx NextSeq 550Dx NovaSeq 6000
Regulatory Status: For In Vitro Diagnostic Use For In Vitro Diagnostic Use For Research Use Only
Key Applications – Diagnostic Mode: Targeted Enrichment (Illumina DNA Prep with Enrichment Dx)
Future Illumina Assays
Future Partner Assays
IVD Assay Development
Targeted Enrichment (Illumina DNA Prep with Enrichment Dx)
TruSight Oncology Comprehensive (EU)
VeriSeq NIPT
Future Illumina Assays
Future Partner Assays
Not available
Key Applications – Research Mode:
  • Whole-Genome Sequencing
  • Targeted DNA Sequencing (high-throughput exome and large custom enrichment panels)
  • Whole-Transcriptome Sequencing
  • Targeted RNA Sequencing (exome, custom enrichment panels)
  • Methylation Sequencing
Explore research applications
  • Targeted DNA Sequencing (lower throughput exome, smaller custom enrichment panels and amplicon)
  • Whole-Transcriptome Sequencing
  • Targeted RNA Sequencing (exome, custom enrichment and amplicon panels, mRNA-seq and gene expression profiling)
  • Cytogenomic Arrays
Explore research applications
  • Whole-Genome Sequencing
  • Whole-Genome De Novo Sequencing
  • Targeted DNA Sequencing (high-throughput exome and large custom enrichment panels)
  • Whole-Transcriptome Sequencing
  • Targeted RNA Sequencing (exome, custom enrichment panels)
  • Methylation Sequencing
Explore research applications
System Software: Integrated ecosystem including DRAGEN Server and Illumina Run Manager Local Run Manager BaseSpace Sequence Hub
Analysis:

Analysis apps for Illumina DNA Prep With Enrichment (RUO and Dx) available with a graphical user interface on the paired DRAGEN server.

Analysis app for Germline (RUO) available with graphical user interface on paired DRAGEN server BCL Conver app (RUO) available with graphical user interface on paired DRAGEN server.

Additional RUO applications enabled through BSSH with a stand-alone DRAGEN server purchased separately.

Local Run Manager Illumina Connected Analytics, BaseSpace Sequence Hub, DRAGEN Server
       

View Dx Platforms Brochure Compare All Illumina Sequencers

Scalable throughput in an FDA-regulated, CE-marked sequencing platform

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Overview Video
System specifications (IVD Mode)

Output range
S2 Flow Cell: ≥ 1 Tb
S4 Flow Cell: ≥ 3 Tb

Paired end reads per flow cell
S2 Flow Cell: ≥ 6.67 B
S4 Flow Cell: ≥ 20 B

Max read length
2 × 150 bp

Run time
S2: ≤ 40 hours
S4: ≤ 45 hours

View All NovaSeq 6000Dx Specs

Popular Products

NovaSeq 6000Dx Library Tube

Peform clinical applications using the IVD-compliant NovaSeq 6000Dx Library Tube for use with the NovaSeq 6000Dx System.

NovaSeq 6000Dx S2 Reagent Kits

This IVD-compliant reagent kit provides one NovaSeq S2 flow cell (with 2-lanes) and reagent consumables to support a single flow cell 300 cycles run on the NovaSeq 6000Dx.

NovaSeq 6000Dx S4 Reagent Kits

This IVD-compliant reagent kit provides one NovaSeq S4 flow cell (with 4-lanes) and reagent consumables to support a single flow cell 300 cycles run on the NovaSeq 6000Dx.

Want to learn more about instrument financing options?

Get up and running quickly with a rental or leasing program designed to work with your budget.

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Reagent Rental Program

Illumina offers a reagent rental program to help labs maximize their budgets while staying competitive. This program is designed to fit the way customers budget for capital purchases and covers all products and countries where we sell direct.

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Optimize your lab performance

Instrument reliability is crucial for your lab. To maximize uptime, we offer remote monitoring and proactive support to detect potential risks before your run. We offer troubleshooting, maintenance, real-time updates, and more—all in one personal dashboard.

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Ready to transform your clinical lab?

With dual operating modes, scalable throughput, and broad flexibility, the NovaSeq 6000Dx will usher in a new era for your clinical laboratory. Contact us today to discuss how the instrument can accelerate your diagnostic and clinical research pursuits.

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