Illumina Connected Multiomics

Illumina Connected Multiomics is a powerful and intuitive cloud-based solution that enables multiomic data analysis and visualization at scale.

Illumina Connected Multiomics
Data sheet PDF 14 MB

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Overview

Illumina Connected Multiomics is an easy-to-use bioinformatics platform that streamlines the analysis of NGS, arrays, and large-scale multiomic data in an intuitive visual user interface. Powerful statistical algorithms, information-rich visualizations, an interactive interface, and cutting-edge genomic tools empower researchers to analyze their data confidently, without the need for advanced informatics expertise.

Consolidate multiomic data analysis on a single scalable platform to accelerate discoveries
Simplify interpretation from complex data sets without the need for bioinformatics expertise
Obtain trusted results with powerful algorithms for data analysis and interactive visualizations
Link results to curated knowledgebases to uncover biological insights with greater confidence
Analyze multiomic data within a security-first infrastructure that conforms to privacy and compliance software regulations

Powerful analysis

Illumina Connected Multiomics leverages analysis tools built using publicly available, industry-standard statistical algorithms, including models for normalization and noise reduction, to uncover patterns across omics layers

Intuitive interface

Preconfigured and customizable analysis options with integration of outputs from DRAGEN secondary analysis in a user-friendly visual interface enables users to explore their multiomic data sets with confidence and ease

Streamlined workflows

Built to provide integrated multiomic workflows from assays to insights, Illumina Connected Multiomics allows users to consolidate their multiomic analyses on a single, scalable platform to accelerate discoveries

Specifications

Instruments	MiSeq System, MiSeqDx Instrument, iSeq 100 System, NextSeq 550 System, NextSeq 2000 System, NextSeq 1000 System, MiSeqDx in Research Mode, MiniSeq System, NextSeq 550Dx in Research Mode, NovaSeq X System, NovaSeq 6000Dx in Research Mode, iScan System, NovaSeq 6000 System, NovaSeq X Plus System, MiSeq i100 System, MiSeq i100 Plus System
Software format	Cloud
Technology	Microarray, Sequencing

Applications

Illumina Connected Multiomics enables high-resolution data analysis across a range of multiomic applications, including proteomics, transcriptomics, epigenomics, and genomics, and modalities, including single-cell and spatial analysis.

Example workflow

Lab

Clarity LIMS

A highly customizable laboratory information management system that allows genomics labs to track samples and manage workflows efficiently and securely.

Run

BaseSpace Sequence Hub

Easy-to-use cloud-based genomic run management and bioinformatics compute and storage environment for secure, high-performing sequencing operations.

Analytics

DRAGEN Secondary Analysis

Accurate, comprehensive, and efficient secondary analysis of next-generation sequencing (NGS) data.

Illumina Connected Analytics

A secure, scalable bioinformatics platform for seamless sequencer integration and flexible workflows.

BaseSpace Apps

BaseSpace Sequence Hub offers a wide variety of NGS data analysis apps for common Illumina sequencing methods.

Insights

Illumina Connected Multiomics

A powerful cloud-based multiomic analysis and interpretation software, enabling sample to insight workflows with interactive visualizations, infrastructure scalability, and secure data management.

Correlation Engine

An interactive omics knowledge base and data search engine that puts private data into biological context with highly curated public omics data.

Related applications and methods

Introduction to spatial transcriptomics technology

A high-resolution, sequencing-based spatial profiling technology for whole-transcriptome analysis within intact tissue architecture.

Genome and methylome sequencing

Achieve simultaneous high-accuracy genome and methylome discovery in a single readout with the Illumina 5-base genome solution.

Multiomics

Use multiomics profiling to multiply discovery power and better connect genotype to phenotype.

Advances using Illumina Connected Multiomics

Leveraging proteomics to understand rare melanomas

Illumina Protein Prep is giving University of Colorado researchers a powerful, unbiased tool to interrogate these unique conditions

Plans and pricing

Illumina Connected Multiomics offers two tiers:

Illumina Connected Software Basic

Includes preconfigured analysis workflows supporting select Illumina assays and is free to use. Requires sufficient iCredits to meet data storage and analysis needs based on throughput.

Illumina Connected Multiomics Professional

Includes preconfigured analysis workflows supporting select Illumina assays and the ability to create new custom workflows for Illumina and select third-party assays. Pathway analysis is enabled with the integration of Ilumina Correlation Engine or KEGG Pathway. Requires purchase of an annual or monthly license and sufficient iCredits to meet data storage and analysis needs based on throughput.

Visit the Order tab to learn more about the differences between these tiers.

For more information on iCredits, visit the iCredits Overview page.

Subscription options

Feature	Basic	Professional
Deployed on Illumina regional instances of AWS cloud	checkmark	checkmark
Complimentary access to Illumina Connected Analytics Basic and Illumina BaseSpace Sequence Hub	checkmark	checkmark
Access to DRAGEN outputs	checkmark	checkmark
Advanced security and compliance	checkmark	checkmark
Default pipelines	checkmark	checkmark
Custom pipelines		checkmark
Select third-party assay support		checkmark
Pathway analysis and integrated Correlation Engine		checkmark
Access	All domain and workgroup members	Seat-based license, 1 assigned user per license

Documentation

Product literature

Illumina Connected Multiomics
Data sheet PDF 14 MB

Support documentation

Illumina Connected Multiomics Support Documentation

Figures

Proteomics

Sample distribution is visualized using a 2D scatterplot based on principal component analysis. Protein clustering patterns are displayed in a heatmap with dendrogram. Dot plot focuses on sample groups based on a specific protein expression. Pathway shows enrichment in one group compared to the other.

Single-cell analysis

Immune cell types are visualized by dimensionality reduction plots (UMAP and t-SNE), pie chart, and bar chart showing high expression of classical monocytes. The table depicts graph-based clustering biomarkers. The heatmap and bubble map show Z-score distributions and value prevalence for significant genes from a comparison. Gene set enrichment analyses figures highlight key biological KEGG pathways.

5-base sequencing

This plot was created using the 5-base methylation QC task by extracting and plotting statistics in the secondary analysis output metric files. From the QC report, we visualize sample-level QC metrics that describe read mapping quality and DNA methylation calling quality, for e.g., percentages of CpG methylation in the samples, in the unmethylated control, and in the methylated controls.

Spatial analysis

Detail of the habenular region of a pregnant mouse brain. The cells are colored by the results of the clustering performed on the data. A UMAP displays the clustering of the cells, and a pie chart shows the relative abundance of each cluster in the dataset.

Resources

Accelerate multiomic discovery with Illumina Connected Multiomics

Illumina Protein Prep assay data is showcased in Illumina Connected Multiomics to interactively explore proteomic data in biological context.

Introducing Illumina Connected Multiomics

Using a wide variety of interactive plots, meaningful patterns, biomarkers and pathways, Illumina Connected Multiomics brings biological data to life.

Illumina Connected Multiomics video library

Explore the Illumina Connected Multiomics YouTube playlist for concise, high-value video insights into multiomic study design, assay workflows, data integration strategies, and actionable applications.

Software and informatics (4)

Illumina Connected Multiomics - Professional License - Trial

20141939

30-day trial for 1 user to access Illumina Connected Multiomics, including pre-configured workflows, custom workflows, and 100 iCredits for compute and storage.

List Price:

Discounts:

Illumina Connected Software – Basic License

20141940

Basic license to Illumina Connected Software including run planning, DRAGEN pipeline analysis, and pre-configured multiomic pipelines. Includes access to Illumina Connected Multiomics - Basic, Illumina Connected Analytics, and BaseSpace Sequence Hub.

List Price:

Discounts:

Illumina Connected Multiomics - Professional Annual License

20141942

1-year license for 1 user to access Illumina Connected Multiomics, including pre-configured and custom workflows with pathway analysis powered by Correlation Engine. Includes access to BaseSpace and Illumina Connected Analytics.

List Price:

Discounts:

Illumina Connected Multiomics - Professional Monthly License

20156707

1 month license for 1 user to access Illumina Connected Multiomics, including pre-configured and custom workflows with pathway analysis powered by Correlation Engine. Includes access to BaseSpace and Illumina Connected Analytics.

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FAQs

Illumina Connected Multiomics supports bulk proteomics, transcriptomics, epigenomics, and genomics, as well as single-cell and spatial transcriptomics.

For information on the data formats supported by Illumina Connected Multiomics, see the Illumina Connected Multiomics online help about Supported Data Types.

Visit out documentation for the most current information.

Visit the BaseSpace Online Help iCredit section for more in-depth information about BaseSpace iCredit usage.

Illumina Connected Software: Illumina iCredit Usage Explorer

No, Illumina Connected Multiomics is only available on Illumina AWS instances. For local cloud installation, contact us at info@illumina.com

Yes. As part of the Illumina Connected Software ecosystem, Illumina Connected Multiomics conforms to the Illumina security-first infrastructure, providing privacy and compliance to software requirements and regulations.

For a complete list of industry-standard statistical algorithms used in Illumina Connected Multiomics visit statistics used in Illumina Connected Multiomics.

Illumina Connected Multiomics provides comprehensive tertiary analysis including QA/QC, annotation, filtering, normalization, batch removal, statistics, exploratory analysis, region analysis, classification, biological interpretation, pathway analysis, and more. Visit Connected Multiomics task actions to learn more.

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