Transforming modern infectious disease surveillance

NGS offers a universal, hypothesis-free research method for use with viruses, bacteria, or parasites

Infectious Disease Surveillance and Monitoring

Genomics is transforming modern infectious disease surveillance, expanding our understanding of pathogen evolution, host–pathogen interactions, and antibiotic resistance. In turn, public health professionals are changing the methods they use to research, monitor, and prevent epidemics and pandemics of high-profile infectious diseases such as influenza, tuberculosis, and Ebola.

Traditional methods of assessing infectious agents include antibody-based testing, real-time PCR, pulsed field gel electrophoresis (PFGE), and multilocus sequence typing (MLST). These methods are typically useful only for a small and defined number of organisms, and data analysis can be subjective.

Human Microbiome Analysis

Next-generation sequencing (NGS) provides a universal, hypothesis-free method for infectious disease surveillance that can be used with viruses, bacteria, or parasites. Genomic analysis with NGS provides high-resolution information to distinguish pathogen strains that differ by as little as one single-nucleotide polymorphism (SNP), and it can replace the need for multiple tests.

Illumina NGS technology delivers rapid results and high-quality data that public health professionals are adopting to identify, track, and respond to infectious disease outbreaks.

Our Perspective on the Novel Coronavirus SARS-CoV-2 Outbreak

The severe acute respiratory syndrome coronavirus SARS-CoV-2 (2019-nCoV) outbreak is an important reminder that the global community must strengthen national and international programs for early detection and response to future disease outbreaks.

Illumina has made our technology available to Chinese health authorities and we are ready to support similar applications and strategies across the globe to improve detection and to enhance our tracking of the epidemiology, evolution, and virulence of SARS-CoV-2.

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Illumina Perspective on the Novel Coronavirus SARS-CoV-2 Outbreak

How to Detect Coronavirus using Illumina Benchtop Systems

A shotgun metagenomics sequencing workflow for effective detection and characterization of coronavirus strains.

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Next-Generation Sequencing Helps Fight Infectious Diseases Globally

NGS technology enabled infectious disease experts to identify and characterize the genome of the novel coronavirus in China.

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Illumina Sequencers Help Characterize and Control Coronavirus

This detailed viral information is enabling public health officials to respond with unprecedented speed and breadth.

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Microbes and Metagenomics Research Review

This summary highlights recent peer-reviewed publications in which researchers used NGS to analyze viral populations, microbial pathogenesis, zoonotic reservoirs, the gut microbiome, and more.

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Microbiology Research Review

Featured Infectious Disease Surveillance Research

 
iSeq Used to Characterize Ebola
Portable iSeq Helps Researchers Characterize Ebola Outbreak

In combination with extensive epidemiological findings, the iSeq 100 System enabled local scientists to analyze transmission patterns and trace the outbreak's origin.

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Interview with Dr. Henrik Westh
Identifying Drug-Resistant MRSA Strains

Researchers use NGS to understand the spread of methicillin-resistant Staphylococcus aureus (MRSA) and identify strains from around the world.

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Seeking the Source of Bacterial Drug Resistance
Seeking the Source of Tuberculosis Drug Resistance

NGS-based targeted deep sequencing enables researchers to identify multi-drug-resistant tuberculosis strains responsible for silent outbreaks.

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Targeted Sequencing with the Pan-Viral Panel
Targeted Sequencing with the Pan-Viral Panel

This NGS workflow enables culture-free detection of viral targets without prior knowledge, even for mutagenic regions.

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Illumina NGS Virology Solutions
Virology NGS Solutions

Illumina NGS offers a comprehensive picture of viruses, host interactions, and phages specific to microbes.

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Influenza Surveillance in China

Learn how researchers at the Jiangsu CDC use Illumina NGS for influenza surveillance.

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Reconstructing Tuberculosis Outbreaks
Reconstructing Tuberculosis Outbreaks

NGS was used to reconstruct outbreaks of tuberculosis in British Columbia, Canada.

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Deep Sequencing of HIV
Deep Sequencing of HIV

Learn about detection of drug resistance variants and tracking of viral haplotypes.

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Diagnosing Infectious Disease with NGS
Diagnosing Infectious Disease with NGS

Dr Peyro-Saint-Paul explains how the CE-IVD marked iDTECT™ Blood Test can be used to detect pathogens in blood samples.

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HIV Variant Calling

Discover a streamlined workflow for HIV variant calling.

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