Making sense of neurological diseases with genomics

Neurogenomics

Genomics technologies such as next-generation sequencing (NGS) and microarrays are accelerating neurogenomics research by revealing the mechanisms behind complex neurological diseases such as Alzheimer’s disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), and psychiatric disorders.

The interplay between heritable and nonheritable mutations, epigenetics, and other factors requires NGS-level analyses to increase our understanding. Arrays facilitate large-scale studies of genetic variants associated with neurological diseases. Illumina offers the NGS and microarray tools needed to make genomic neuroscience research possible.

Genomic Architecture of Neurodegenerative Disease

Large-scale genomic analysis studies provide insights into genes and biological pathways associated with diseases like Alzheimer’s and Parkinson’s.

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TruSeq Neurodegeneration Panel: This NGS panel covers 118 risk genes associated with common neurodegenerative diseases, including Alzheimer’s disease, Parkinson's disease, ALS, and others.

Infinium PsychArray BeadChip: This array allows researchers to evaluate genetic variants associated with common psychiatric disorders.

Kailos TargetRich PGxComplete: This enrichment-based targeted sequencing research panel covers 43 genes associated with responses to ~100 medications.

Kailos Blue Analytics: These solutions provide sequencing quality assessment, alignment, and variant calling in output formats suitable for use with a variety of reporting solutions.

How Scientists Use a Neurodegeneration Sequencing Panel

See how the TruSeq Neurodegeneration Panel helps researchers investigate the genetic landscape of Alzheimer's, Parkinson's, and other neurological diseases.

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Learn how integrating whole-genome or whole-exome sequencing data with transcriptome information (from RNA-Seq) and epigenetic information (from methylation arrays) in stem cells and tissue types of interest can help identify genes and pathways that have a role in neurological diseases.

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Stem Cells
Genetic Contributions of Cognitive Control

Neuroscience researchers use NGS to identify variants for a microarray designed for ADHD, autism, and schizophrenia studies.

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Large-Scale Genetic Risk Profiling in Dementia

Experts discuss the genetics of dementia in this podcast episode, hosted by the UK Dementia Research Institute and Illumina.

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NGS for Variant Discovery in Neuroscience Research

Dr. Franco Taroni uses targeted sequencing to uncover novel genomic variants associated with metabolic and neurological disorders.

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Untangling Alzheimer's Secrets

Amanda Myers, PhD uses a combination of genomics, transcriptomics, and proteomics to identify networks of data and explain the complexity of Alzheimer’s disease.

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Untangling Alzheimer's Secrets
Neuro Consortium Array

Researchers in the neurogenomics community contributed content for the Neuro Consortium Array, a high-density array featuring over 180,000 markers associated with common neurodegenerative diseases. The array offers a high-throughput genotyping solution for fine mapping and replication of disease-associated variants.

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Neurodegeneration Sequencing Consortium

Through this consortium, scientists selected content for the TruSeq Neurodegeneration Panel based on recent scientific findings. The TruSeq Neurodegeneration Panel offers a high-throughput approach to identifying and validating variants associated with risk for multiple neurodegenerative diseases.

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Integrating Genomic Data for Neurobiology Research
Integrating Genomic Data for Neurobiology Research

Jonathan Mill, PhD and his team use genomics to better understand neuropsychiatric diseases.

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Gene Panel and Array Finder
Gene Panel and Array Finder

Identify sequencing panels or microarrays that target your genes of interest.

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Target Enrichment
Target Enrichment

Target enrichment captures genomic regions of interest by using hybridization to target-specific biotinylated probes.

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Driving ALS Discovery with Integrative Genomics
Driving ALS Discovery with Neurogenomics

Jan Veldink, PhD shares how integrative genomics helped drive his ALS research and identify NEK1 as an ALS gene.

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