Understanding epigenetic modifications and their impact on gene regulation

Powerful solutions for studying heritable changes outside of the DNA sequence

Epigenetics

Epigenetics is the study of heritable changes in gene activity caused by mechanisms other than DNA sequence changes. Epigenetic analysis research can involve studying alterations in DNA methylation, DNA-protein interactions, chromatin accessibility, histone modifications, and more.

Illumina offers a broad portfolio of next-generation sequencing (NGS)- and array-based epigenetic analysis tools that provide robust, simple-to-use, and cost-efficient solutions for studying these epigenetic modifications and their impact on gene regulation. By working with leading epigenomics experts, Illumina ensures its solutions meet the field's rapidly evolving needs.

A Fuller Picture of Gene Expression Profiling

This ebook discusses genomics applications in gene expression and regulation research. See how workflows can impact study results.

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DNA Methylation Analysis

Investigate methylation patterns quantitatively across the genome using sequencing- and array-based techniques.

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DNA-Protein Interaction Analysis

Gain insight into protein and DNA interactions. Investigate the potential impact of chromatin modifications and local structural changes on gene expression.

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Featured Epigenetics Research

 
Mysteries of Metastasis
The Epigenetics of Metastasis

Researchers use methylation arrays and NGS to investigate the epigenetics behind cancer metastasis.

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Breast Cancer
NGS Proves Invaluable for Biomarker Discovery

Researchers use NGS to study DNA-protein interactions, analyze gene expression, and assess coding exons.

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Epigenetics and Obesity
Epigenetics and Obesity

Epigenome-wide association studies identify cell signaling disruption that potentially contributes to the negative downstream effects of a high body mass index.

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Cancer Epigenetics
Cancer Research with RNA-Seq

Studies of epigenetic alterations in cancer, such as aberrant methylation and transcription factor binding, can provide insight into important tumorigenic pathways. Learn more about epigenetic changes in cancer.

Complex Disease Research
Microbial RNA-Seq

Genome-wide methylation profiling can help researchers understand the mechanisms behind complex diseases. Aberrant methylation has been implicated in complex disorders such as Alzheimer’s disease and asthma. Learn more about complex disease research.

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Epigenome Roadmap
Epigenome Roadmap

A collection of research papers that systematically characterize epigenomic landscapes in primary human tissues and cells.

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Epigenetic Contributions to Addiction
Epigenetic Contributions to Addiction

Marilee Morgan discusses the use of NGS to correlate epigenetic signatures with brain image scans of substance abusers.

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Nutrition: Matter Over Mind
Nutrition: Matter Over Mind

A review of current research into the impact of epigenetics on human health.

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Learn Epigenetics
Learn Epigenetics

A SEPA-funded initiative at the Genetic Science Learning Center at the University of Utah.

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Nature vs. Nurture
Nature vs. Nurture

An introduction to epigenetics and the role it plays in cancer, genetic disease, and development.

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Methylation Field Guide
Methylation Field Guide

A comprehensive guide on array and sequencing-based methylation methods.

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Epigenome Blueprint
Epigenome Blueprint

A consortium generating 100 reference epigenomes to understand gene activation and repression in healthy and diseased human cells.

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References

*Data calculations on file. Illumina, Inc., 2017.