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Pillar oncoReveal panels

Explore library prep kits that enable a simplified, rapid NGS workflow for targeted oncology research applications

A pan-cancer portfolio to equip your research lab

Illumina has partnered with Pillar Biosciences to offer library prep panels as part of a simplified, rapid next‑generation sequencing (NGS) workflow for oncology research. Panels include genes associated with solid tumors and hematological malignancies, as well as those designed for liquid biopsy, and can be run on Illumina benchtop sequencing systems. DRAGEN software and Illumina Connected Insights are available for analysis.

The workflow provides accurate variant detection across a range of DNA and RNA variant types, even with limited nucleic acid input or poor sample quality. These flexible solutions improve lab efficiency and reduce "no calls" and repeat testing to simplify data interpretation.

Front view of a male scientist holding the tip of a single pipette in a tube then pulling it out while setting the tube down.

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Pillar oncoReveal Multi-cancer CNV + RNA Fusion Panel

A pan-cancer panel with combined DNA/RNA content, utilizing the single-tube SLIMamp workflow for fast library prep and turnaround time.

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Pillar oncoReveal Myeloid Panel

A 58-gene pan-cancer panel with combined DNA content, utilizing the single-tube SLIMamp workflow for fast library prep and turnaround time.

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FAQ

All oncoReveal panels can be run on the MiSeq i100 Series for the fastest turnaround times. The panels are also compatible with MiSeq and MiSeqDx (in RUO mode) instruments and make a great compliment to TruSight Oncology 500 when run on the NextSeq 550, NextSeq 550 Dx (in RUO mode) or NextSeq 1000/2000. 

OncoReveal panels are designed using stem-loop inhibition mediated amplification (SLIMamp) chemistry enabling highly multiplexed PCR in a single tube. Tagged primers form stem-loop structures, selectively blocking unwanted amplification, reducing hands-on time, and minimizing errors. The technology’s streamlined workflow improves laboratory efficacy while maintaining high sensitivity for variant detection even at low allele frequencies.

Going from sample to result can be as fast as <24 hours for oncoReveal panels sequenced on the MiSeq i100 Series with DRAGEN and Illumina Connected Insights for analysis. Panel assay times range from < 8–11 hours.

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