Gain insights into immunological diseases with genomics

Immunogenomics Research

Genomic analysis technologies can advance immunology research by elucidating immune cell function and signaling. The causes of complex autoimmune diseases (such as lupus, rheumatoid arthritis, and multiple sclerosis) and other immunological disorders are still poorly understood.

Immunogenomics solutions from Illumina can help immunology researchers gain insight into potential autoimmune disease mechanisms, the immune repertoire, and the functional consequences of immune-related genetic variation. Next-generation sequencing (NGS) provides the quality, throughput, and read lengths required by the research community to map the immune response at high resolution. Microarrays offer high-density content for large-scale studies of genetic variation in the human immune system. 

Immunology Research Publication Review
Immunology Research Review

View summaries of peer-reviewed publications showing the diverse ways in which immunologists use NGS.

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NGS is proving to be a powerful immunogenomics research tool to map the vast repertoire of immune cells that are capable of recognizing a seemingly boundless array of targets.1 Repertoire sequencing has enabled researchers to identify unique receptor variants found in individuals with susceptibility to autoimmune disorders, hematological malignancies, and other diseases.2  

T Cell Receptor Repertoire Analysis

Researchers unravel disease mechanisms by sequencing the T cell receptor (TCR) repertoire as well as mitochondrial DNA and piwi-interacting RNA.

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Immunogenomics Research Articles

 
Tumor-Specific HLA Ligands
Precision Immunotherapies Using Tumor-Specific HLA Ligands

RNA-Seq and human leukocyte antigen (HLA) typing are increasing the power and efficiency of a target discovery platform.

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Targeted DNA Analysis
HLA Genetics & Autoimmune Disease

Researchers query the genome with NGS and perform high-throughput genotyping to identify novel risk loci for immune-mediated disease.

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Breast Cancer
NGS Proves Invaluable for Biomarker Discovery

Researchers use NGS for cancer gene expression analysis, immunology research, and immunotherapy biomarker studies.

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AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.

AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.

AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.

Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.

Single Cell Omics and Cellular Immunology Research

In episode 45 of the Illumina Genomics Podcast, Dr. Shalin Naik discusses the use of single cell genomics to understand the immune system.

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Using Single-Cell Technologies to Drive Deeper Immune Discoveries
Single Cells

See how multi-omic analysis with single-cell tools allowed the discovery of new biomarkers in rare immune cell types, leading to high content flow cytometry characterization experiments.

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Using Immunogenomics to Decode the Anti-Tumor T-Cell Repertoire
T cells and tumor cells

Kellie Smith, PhD, Assistant Professor of Oncology at Johns Hopkins University School of Medicine, presents her research on understanding the interplay of cancer neoantigens with the immune response.

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Understanding Tumor Immunogenicity

NGS can help researchers identify mutations that enable tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity.

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T Cell-Mediated Immunity
Cancer Research
Cancer Research

Sequencing and microarray technologies support a broad range of cancer research applications, from DNA to RNA analysis, epigenetics, and more. Learn more about cancer genomics research.

Complex Disease Genomics
Complex Disease Genomics

Illumina sequencing is introducing new avenues for understanding autoimmune and rheumatic diseases, atherosclerosis, psychiatric, and other disorders on a molecular level. Learn more about complex disease research.

Driving IBD Discovery with Integrative Genomics
Driving IBD Discovery with Immunogenomics

Dr Carl Anderson discusses integrated research approaches in inflammatory bowel disease (IBD) research.

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Cells and Antibodies
Unravelling the Mystery of Autoimmunity

Dr. Carola Vinuesa discusses how NGS can unravel the complex interaction of cells and molecules that regulate autoimmunity.

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Genomics and Immune Diseases

Dr. Janna Saarela discusses use of genomics to identify mechanisms behind common and rare immune diseases.

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References
  1. Woodsworth D.J., Castellarin M., and Holt R.A. Sequence analysis of T-cell repertoires in health and disease. Genome Med. 2013; 5:98.
  2. Robins H. Immunosequencing: applications of immune repertoire deep sequencing. Curr Opin Immunol. 2013; 25: 646-652.