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COVID-19 Host Genetics & Immune Response Profiling

Coronavirus

Investigating COVID-19 Host Genetics

Uncovering the underlying genetic factors associated with COVID-19 host susceptibility and studying differences in immune responses may help unravel the complexities of the disease and reveal future therapeutic targets. It is crucial to identify genetic variants linked to COVID-19 susceptibility or protection and profile differences in individual immune system responses during the course of the disease. Next-generation sequencing (NGS) and microarray technologies allow researchers to interrogate host genetic variation and characterize the molecular mechanisms that drive immune responses.

The key benefits of using Illumina technologies to study host genetic variation and profile the immune response to SARS-CoV-2 include:

  • Scalability and flexibility to screen diverse sample sets, with high-throughput and low-throughput options
  • Solutions to enable a multi-omic approach to understand host genetics and immune responses
  • Data analysis and interpretation solutions to match your project scale

Methods for Host Risk & Immune Response Profiling Studies

Application Goal Recommended Methods
Host genetics research
  • Define host genetic risk factors
  • Identify genetic variants linked to protection
Host immune response profiling
  • Understand biology/mechanism of immune response
  • Identify biomarkers for disease progression
Microbiome & host response
  • Study effect of microbiome in COVID patients
Illumina Sequences Genomes for UK-Wide COVID-19 Study
Data from severely ill patients may help us understand the genetics of susceptibility. Sequencing the entire human genome may identify genetic variations that help explain why the COVID-19 pandemic is life-threatening for some people but not others.
Webinar: COVID-19 Host Genetics Initiative

Mark Daly, PhD discusses a global effort to identify host genetics contributions to COVID-19 disease susceptibility and severity.

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Using Genomics to Study COVID-19 Host Genetic Variability

Dr. Lee Murphy’s core lab at the University of Edinburgh applies a genomic approach to study host genetic variability in disease progression and outcome in SARS-CoV-2 hospitalized patients. The team and collaborators perform genotyping and WGS on DNA samples, as well as mRNA sequencing on the NextSeq 2000 System.

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Environment for COVID-19 Host Genetics & Immune Response Studies
BaseSpace Correlation Engine enables hypothesis validation around important pathways, biomarkers, and potential drug candidate leads, to help address the COVID-19 crisis. 

Featured Host Genetics & Immune Response Profiling Publications

High-throughput SARS-CoV-2 and host genome sequencing from single nasopharyngeal swabs
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Presence of Genetic Variants Among Young Men with Severe COVID-19
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COVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Read Paper
Get help finding the right solutions for your host genetics and immune response studies.

Related Solutions

Microbiome Analysis

The study of microbial communities found in and on the human body allows researchers to understand the role of microbes in health and disease.

Shotgun Metagenomics

A DNA sequencing method that enables comprehensive sampling of all genes in all organisms in a given complex microbial sample.

Complex Disease Research

Complex diseases result from a combination of genetic and environmental factors. Array and sequencing technologies can help reveal the underpinnings of these diseases.

Cell & Molecular Biology

Expand cell and molecular biology research beyond conventional methods with next-generation sequencing.

Single-Cell RNA-Seq

With single-cell RNA-Seq, researchers can study cellular differences that are often masked by bulk sampling.