Investigating COVID-19 Host Genetics
Uncovering the underlying genetic factors associated with COVID-19 host susceptibility and profiling individual immune system responses may help unravel the complexities of the disease and reveal future therapeutic targets. It is crucial to identify genetic variants linked to COVID-19 disease severity, and study immune response differences such as inflammatory cytokine, T cell, and NK cell gene expression signatures. Next-generation sequencing (NGS) and microarray technologies can help researchers interrogate host genetic variation and characterize the molecular mechanisms that drive immune responses.
The key benefits of using Illumina NGS and array technologies to study host risk and immune response include:
- Scalability and flexibility to screen diverse sample sets, with high-throughput and low-throughput options
- Solutions that allow a multi-omic approach to analyze host genetic variation and profile immune transcript and epigenetic signatures
- Data analysis and interpretation solutions to match your project scale
Methods for Host Genetics & Immune Response Profiling Studies
| Application | Goal | Recommended Methods |
|---|---|---|
| Host genetics research |
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| Host immune response profiling |
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| Microbiome & host response |
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Illumina Sequences Genomes for UK-Wide COVID-19 Study
Data from severely ill patients may help us understand the genetics of susceptibility. Sequencing the entire human genome may identify genetic variations that help explain why the COVID-19 pandemic is life-threatening for some people but not others.Featured Workflows
Webinar: COVID-19 Host Genetics Initiative
Mark Daly, PhD discusses a global effort to identify host genetics contributions to COVID-19 disease susceptibility and severity.
View WebinarUsing Genomics to Study COVID-19 Host Genetic Variability
Dr. Lee Murphy’s core lab at the University of Edinburgh applies a genomic approach to study host genetic variability in disease progression and outcome in SARS-CoV-2 hospitalized patients. The team and collaborators perform genotyping and WGS on DNA samples, as well as mRNA sequencing on the NextSeq 2000 System.
View Video
Environment for COVID-19 Host Genetics & Immune Response Studies
BaseSpace Correlation Engine enables hypothesis validation around important cell signaling and immune system pathways, biomarkers, and potential drug candidate leads, to help address the COVID-19 crisis.Related Publications
Immunology of COVID-19: Current State of the Science
Read ReviewPresence of Genetic Variants Among Young Men with Severe COVID-19
Read PaperCOVID-19 severity correlates with airway epithelium–immune cell interactions identified by single-cell analysis
Read PaperGet help finding the right solutions for your host genetics and immune response studies.
Related Solutions
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A DNA sequencing method that enables comprehensive sampling of all genes in all organisms in a given complex microbial sample.
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