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Infinium OncoArray-500K BeadChip

This comprehensive, high-density microarray kit enables research into cancer predisposition and risk.

~2,304 samples per week

Sample throughput

Fixed markers: ~500,000 Custom marker add-on capacity: Up to 120,000 (with + kit versions)

Number of markers

See full details in the specifications table

Overview

The Infinium OncoArray-500K contains 500,000 SNPs with a genome-wide backbone of 250,000 tag SNPs. Additional SNPs include genetic variants associated with breast, colorectal, lung, ovarian, and prostate cancers plus SNPs covering ancestry, quantitative traits, pharmacogenetics, and fine-mapping of common cancer susceptibility loci. To support additional research requirements, the Infinium OncoArray-500K can be tailored to incorporate up to 120,000 custom beadtypes.*

The Infinium OncoArray-500K was developed in collaboration with leading experts from the OncoArray consortium†, and draws on many of the features of the successful Collaborative Oncological Gene-environment Study (iCOGS) array1. Designed with candidate SNPs identified by the consortium, the OncoArray provides a cost-effective means to assess candidate variants potentially associated with cancer risk.

The Infinium OncoArray-500K uses a 24-sample high-throughput screening (HTS) BeadChip to enable maximum throughput, productivity, and genotyping accuracy. Using the proven iScan System, the Infinium OncoArray-500K is designed to combine affordability with high-density content, providing insight into the relationship between gene variants and cancer predisposition in five of the most prevalent cancers.

* For additional information about custom add-on content, contact your Illumina account manager or sales specialist.

View Manifest (Array Content) Files

Specifications

Assay type Infinium HTS
Automation capability Automated array loader, Liquid handling robot(s)
Input quantity 200 ng DNA
Instruments iScan System
Method Targeted genotyping array
Nucleic acid type DNA
Number of markers Fixed markers: ~500,000
Custom marker add-on capacity: Up to 120,000 (with + kit versions)
Sample throughput ~2,304 samples per week
Species category Human
Technology Microarray
Variant class Single nucleotide polymorphisms (SNPs), Germline variants, Structural variants, Insertions-deletions (indels), Copy number variants (CNVs)

Required products

Match your chosen kit size to the number of samples you run at a time. Each kit is processed as a single batch and is not designed to be divided across multiple experiments. If you are processing several low-throughput batches, order multiple small kits.

/ Results

Applications

Example workflow

1
Method
2
Process and Scan
3
Analyze

Related applications and methods

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Documentation

Product literature
Support documentation

Infinium OncoArray-500K BeadChip Kit (48 samples)

WG-355-1001

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 2 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 48 DNA samples.

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Infinium OncoArray-500K BeadChip Kit (288 samples)

WG-355-1002

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 12 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 288 DNA samples.

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Infinium OncoArray-500K v1.0 BeadChip Kit (1152 samples)

WG-355-1003

Each Infinium OncoArray-500K BeadChip can process twenty-four samples and analyze >500,000 loci. Each package contains 48 BeadChips, along with reagents for amplifying, fragmenting, hybridizing, labeling and detecting 1152 DNA samples.

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Infinium OncoArray-500K+ BeadChip Kit (48 samples)

WG-355-1011

Infinium OncoArray-500K+ v1.0 (48 samples)

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Infinium OncoArray-500K+ BeadChip Kit (288 samples)

WG-355-1012

Infinium OncoArray-500K+ v1.0 (288 samples)

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Infinium OncoArray-500K+ BeadChip Kit (1152 samples)

WG-355-1013

Infinium OncoArray-500K+ v1.0 (1152 samples)

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References

1. www.nature.com/icogs/primer/cogs-project-and-design-of-the-icogs-array

† The OncoArray consortium is an international collaboration of leading experts from the NCI-supported Genetic Association and Mechanisms in Oncology (GAME-ON) consortium, Genome Canada, Genome Quebec, and Cancer Research UK.

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