Informatics

DNA sequencing data analysis

Transform raw DNA sequencing data into meaningful results

Simple DNA sequence analysis tools

Sequencing generates large volumes of data, and the analysis required can be intimidating. Fortunately, the analytical tools available today take most of the manual work out of the next-generation sequencing (NGS) data analysis process, making it easier for you to glean meaningful insights quickly.

User-friendly Illumina informatics tools smooth the process of analyzing sequencing data, so you can spend more time doing research and less time configuring workflows. Our NGS software packages perform analysis after the on-instrument data processing is complete for optimized turnaround times.

Close up clip of female scientist closely looking at the screen of a NextSeq 1000/2000 sequencer, additional hand of a different scientist not visible explaining results.

Scaling from exomes to genomes

DRAGEN secondary analysis software enables GeneDx to scale to whole-genome analysis while keeping costs low, turnaround times short, and accuracy high.

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Benefits of DNA sequencing data analysis with Illumina software solutions

Data generated on Illumina sequencing instruments can be automatically transferred and stored securely in Illumina Connected Analytics and BaseSpace Sequence Hub. BaseSpace Sequence Hub features a collection of expert-preferred NGS data analysis apps that support a broad range of studies and simplify NGS data management. These apps provide scalable bioinformatics solutions for analyzing DNA sequencing data and other Illumina data.

Illumina DRAGEN (Dynamic Read Analysis for GENomics) secondary analysis software provides highly accurate, rapid analysis of NGS data, including data from whole-genome, exome, and targeted DNA sequencing experiments.

Available in Illumina Connected Analytics, BaseSpace Sequence Hub, or on-premises, DRAGEN secondary analysis offers a variety of data analysis pipelines, ranging from DRAGEN Germline to DRAGEN Somatic (tumor–normal and tumor-only modes), DRAGEN Joint Genotyping, DRAGEN Methylation, and more.

In addition, DRAGEN software uses lossless genomic data compression to compress and decompress FASTQ files rapidly. This technology reduces the data storage footprint by as much as 5× while preserving data integrity.

Discover DRAGEN secondary analysis software

Learn about BaseSpace Sequence Hub software

Explore the Illumina Connected Analytics platform

Flexible DNA sequencing data analysis

DRAGEN secondary analysis, BaseSpace Sequence Hub, and Illumina Connected Analytics software solutions offer:

Genome insight

Acquire DNA sequence analysis insights, regardless of bioinformatics experience.

Application support

Perform a broad range of research applications, including whole-genome, targeted, and exome sequencing data analysis, as well as methylation sequencing, metagenomics studies, and more.

Instrument integration

Integrate with Illumina sequencing systems to support operations at scale.

Sequencing reports

Present DNA sequencing data results in easy-to-interpret reports.

Data management

Share, access, and integrate data within the scientific community to amplify the value of individual data sets.

Featured DNA sequencing software tools

Method Featured tool
Whole-genome sequencing

DRAGEN Germline

DRAGEN Somatic
Tumor-normal sequencing DRAGEN Somatic
Exome sequencing DRAGEN Enrichment
Amplicon sequencing BaseSpace DNA Amplicon
Methylation sequencing DRAGEN Methylation Pipeline
16S rRNA sequencing BaseSpace 16S Metagenomics
Learn more about DNA sequencing
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Sequencing data examples for common workflows

Coverage histogram from whole-genome sequencing

Variant reporting from whole-genome sequencing

Coverage uniformity from exome sequencing

Alignment summary from targeted resequencing

View sample data sets

See sample data sets for various methods in BaseSpace Sequence Hub, our genomics cloud computing environment, or test BaseSpace apps and evaluate results interactively.
Note that a customer login is required to access BaseSpace Sequence Hub and view specific data sets.

Learn more about BaseSpace Sequence Hub

Register for BaseSpace Sequence Hub

Browse demo data in BaseSpace Sequence Hub

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Interpretation of DNA sequencing data

Access powerful turnkey bioinformatics tools that empower you to turn DNA sequencing data and other genomic information into biological insights.

Correlation Engine

Access a curated library of phenotypic and molecular data to compare and correlate with your DNA sequencing data.

Emedgene software

Explore software that streamlines variant interpretation for rare disease genomics and other germline research applications with explainable AI and automation.

Illumina Connected Multiomics

Discover this powerful, intuitive cloud-based solution which enables multiomic data analysis and visualization at scale.

Speak to a specialist

Talk to an expert to learn more about DNA sequencing data analysis solutions.

Additional resources

View these resources and technical tips to learn how to analyze and interpret data from DNA sequencing experiments.

Developer portal

Access user guides, release notes, and additional technical information.

Illumina informatics news

Keep up with the latest tools and functionality in the Illumina software and informatics portfolio, with spotlights on useful research methods and data examples.

Genomic data storage and security

Store, process, and share large quantities of NGS and other genomic data securely in the cloud with built-in speed and scalability.