The DRAGEN Platform can process NGS data for an entire human genome at 30× coverage in about 25 minutes on premise vs. > 15 hours with a traditional CPU-based system. It set two world speed records for genomic data analysis.1,2
The DRAGEN Platform can reduce on-premise investments in server clusters and utilization of cloud computing resources.
In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.3
The DRAGEN Platform analyzes sequencing data from whole genomes, whole exomes, targeted panels, germline and somatic datasets, and RNA sequencing experiments.
The DRAGEN Platform enables labs of all sizes and disciplines to do more with their genomic data. The DRAGEN Platform uses highly reconfigurable field-programmable gate array technology (FPGA) to provide hardware-accelerated implementations of genome analysis algorithms, such as BCL conversion, mapping, alignment, sorting, duplicate marking, and haplotype variant calling. Fundamental features of the DRAGEN Platform address common challenges in genomic analysis, such as lengthy compute times and massive volumes of data.
Without compromising accuracy, the DRAGEN Platform delivers quickness, flexibility, and cost efficiency. The reprogrammable nature of the DRAGEN Platform enables Illumina to develop custom algorithms and allows for improvements to accommodate future applications.
DRAGEN Platform on-premise and in the cloud offerings enable you to select the DRAGEN Platform that best meets your needs.
DRAGEN pipelines can be used on-premise, or cloud-based options are available at BaseSpace Sequence Hub.
|Illumina DRAGEN Germline Pipeline||The DRAGEN Germline Pipeline provides end-to-end (BCL ➝ VCF) NGS analysis, including advanced error model calibration for increased accuracy, and repeat expansion detection and genotyping through Illumina Expansion Hunter.|
|Illumina DRAGEN Somatic Pipeline||The DRAGEN Somatic Pipeline includes tumor-only and tumor–normal modes, designed for detecting somatic variants in tumor samples|
|Illumina DRAGEN RNA Gene Fusion Detection Pipeline||The DRAGEN RNA Gene Fusion Detection Pipeline performs transcriptome analysis starting with splice junction discovery and alignment, followed by gene fusion detection.|
|Illumina DRAGEN Joint Genotyping/Population Pipeline||The DRAGEN Joint Genotyping/Population Pipeline calls variants jointly across multiple genomes and scales to thousands of samples at expedited speeds with uncompromising accuracy.|
|Illumina DRAGEN CNV Pipeline||The DRAGEN CNV Pipeline performs copy number variant (CNV) analysis for germline and somatic exomes and genomes. Various levels of filtering can be applied to mitigate false positives before emitting the final calls.|
|Illumina DRAGEN Methylation Pipeline||The DRAGEN Methylation Pipeline offers multiple operating modes, including reference-only alignment and annotation-assisted.|
|Illumina DRAGEN Map + Align Pipeline||The DRAGEN Map + Align pipeline is capable of ultra-rapid mapping and aligning DNA and RNA for both exomes and genomes.|
|DRAGEN Reference Builder||This app accepts FASTA files, and builds the proprietary reference used by the DRAGEN apps.|
Collaborators Anthony Philippakis from The Broad Institute, and Susan Tousi of Illumina, discuss how integration of GATK with Illumina sequencers and implementation of the DRAGEN Platform may facilitate hardware acceleration and standardization of data analysis.View Video
The DRAGEN pipeline processed 1,000 whole pediatric genomes in two hours and twenty-five minutes. The feat set the set the Guinness World Records title for Fastest time to analyze 1,000 human genomes1.Read Article
A Guinness world record was set for Fastest Genetic Diagnosis in 19.5 hours. The DRAGEN Platform was used to significantly increase the speed of mapping and aligning genomic data once sequenced.2Read Article
In the 2018 PrecisionFDA Hidden Treasures – Warm Up Challenge, The DRAGEN Platform received the highest score in five out of six accuracy measures for whole-genome variant calling among platforms that recognized all 50 variants.3Read Article
The DRAGEN Platform can be used for numerous applications in the biological sciences.
Rapidly analyze the sequenced genomes; accelerate reanalysis as computational tools improve over time.
Reduce time required for genomic analysis, when fast results can be a critical factor.
Stay ahead of the continuing analysis demand with hardware-accelerated algorithms.
Analyze animals and plants of varying genomic complexities, using a provided reference.
Analyze targeted exome data with rapid turnaround and high accuracy to ensure reproducibility and high-quality results.