Expand biological discovery with the power of high-throughput multiomics
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The NovaSeq X Series delivers the scalable sequencing power and flexibility to support a broad range of methods for interrogating the genome, epigenome, transcriptome, and proteome. Engineered to output data with the highest integrity, the NovaSeq X Series makes even the most data-intensive research accessible with industry leading speed and throughput.
Unleash discovery power across multiple omes with innovations designed for the NovaSeq X Series:
Flexibility
Dual-flow cell architecture and up to 16 individually addressable lanes support broad omic products and applications. Powerful software portfolio from Illumina streamlines data analysis and interpretation across diverse workflows.
Scalability
Multiple cycle kits support a wide range of scalable options. The NovaSeq X Plus System and 1.5B, 10B, and 25B flow cells enable data-intensive multiomic studies at a broader and deeper scale than ever before.
Efficiency
Reduced touch points and steps allow faster and easier workflows from sample preparation to data interpretation. Individually addressable lanes help tailor sequencing data per library.
Cost
Process more samples and access more omes with up to 3× higher accuracy.1 The 25B flow cell increases the number of samples by up to 2.5× for the same budget.2
The time is now for multiomics to address complex biological questions. Watch the video to discover how scientists are gaining an advantage in their sample-to-discovery journey through the power of the NovaSeq X Series.
Technical note spotlight
Learn how you can achieve high-throughput, genome-scale Perturb-Seq experiments with NovaSeq X 25B flow cells. In this technical note, in collaboration with Single Cell Discoveries, we demonstrate a large-scale CRISPR interference workflow. By leveraging the speed and scale of NovaSeq X and 25B flow cells, you will also get insights on how they are making high quality 1M cell Peturb-Seq experiments accessible and efficient.
A broad portfolio of high-throughput Illumina and third-party solutions to interrogate the genome, epigenome, trancriptome, and proteome.
The NovaSeq X and NovaSeq X Plus Sequencing Systems provide exceptional throughput and accuracy for your data-intensive applications at scale.
Experience the power of our secure and flexible bioinformatics platform, designed to operationalize informatics workflows and drive groundbreaking scientific insights.
The NovaSeq X Series makes multiomics accessible to enable discoveries that were previously out of reach. Explore products and reagents, with supporting application notes, resources, and relevant analysis solutions to interpret results for omics workflows below.
By studying the genome, researchers can use information about the structure, function, and sequence of DNA to better understand its role in health and disease.
A rapid and flexible workflow for sensitive whole-genome sequencing.
A fast, robust, and flexible workflow for a wide range of DNA input types.
The fastest and most flexible targeted DNA sequencing solution from Illumina.
A highly sensitive library preparation solution to detect low-abundance mutations from cell-free DNA samples. Learn more in our Data Sheet.
Explore products for Illumina Complete Long Read sequencing.
The transcriptome includes all RNA molecules in an organism and is an important area of study to understand the function of the genome, which can reveal insights into diseases and drug discoveries.
Get an accurate measurement of gene and transcript abundance and detect both known and novel features in coding and multiple forms of noncoding RNA. Learn more in our Data Sheet.
A fast, integrated workflow for producing enriched and indexed sequencing libraries from a broad range of sample types and RNA input quantities. Learn more in our App Note.
A streamlined solution for clear and comprehensive analysis across the coding transcriptome for discovery of features such as novel isoforms, gene fusions, and allele-specific expression. Learn more in our Data Sheet.
Read how the Illumina BaseSpace Sequence Hub now supports ScaleBio’s Single Cell RNA Sequencing Kit, a combinatorial indexing and instrument-free approach to achieve highly multiplexed library preparation on hundreds of thousands of cells for single cell RNA analysis.
High-throughput spatial sequencing platform that enables whole transcriptome analysis of fresh frozen tissue at single-cell scale resolution.
Measure gene expression across tens of thousands of single cells and analyze cellular heterogeneity.
Learn how spatial transcriptomics experiments combine molecular and morphological characterization to provide a previously inaccessible view of tissue biology.
Read this Press Release to learn how Illumina plans on developing single-cell technologies to support the latest multiomics solutions.
Download this eBook to learn how to get accurate, versatile, and integrated data analysis solutions for high-impact research with Illumina Connected Softwar
Epigenomics is the complete study of epigenetic changes of many genes within a cell or organism other than DNA sequence changes.
Read more about whole Genome bisulfite sequencing (WGBS) for DNA methylation studies to quantify base-level methylation.
Connect single-cell epigenome and transcriptome results for a holistic view of gene regulation from the same single cells in this Technical Note.
Explore products such as the Illumina Tagment DNA TDE1 Enzyme and Buffer Kits to analyze chromatin accessibility in ATAC-Seq experiments. Also, see resources for ATAC-Seq and a webinar on how this method was used in single-cell experiments and more.
Learn more about biomodal’s duet multiomics solution +modC data that now available on Illumina BaseSpace Sequence Hub.
Proteomics is the complete study of the structure and function of proteins in an organism. The development of high-throughput proteomics using NGS can advance biomarker discoveries and improve our understanding of cellular functions and diseases.
In this Application Note, see how to use methods such as BEN-Seq (bulk epitope and nucleic acid sequencing) and CITE-Seq (cellular indexing of transcriptomes and epitopes sequencing) to analyze protein and gene expression profiling in Th1 cells.
Learn how CITE-Seq can simultaneously analyze the transcriptome and protein expression at single-cell resolution. In addition, see how researchers use similar methods to reveal new cell types and states associated with disease in this article.
Learn how to leverage the DRAGEN Single-Cell RNA app on the Illumina BaseSpace Sequence Hub to analyze multiplexed samples (mRNA and protein).
Aptamer-based proteomics assay to identify and quantify ~6000 unique human proteins. Currently in an early access, limited release. Available in 2025.
Read this Technical Note to learn how to leverage Olink Explore and Illumina sequencing systems to perform high-throughput protein profiling for biomarker and drug discovery studies.
See how to combine spatial information with protein and RNA expression using NanoString’s GeoMx DSP platform and Illumina’s BaseSpace Sequence Hub, a cloud-based genomics hub for NGS data management and analysis. See the related Application Note to see how it can resolve the tissue architecture of astrocytoma and glioblastoma.
Illumina offers a comprehensive portfolio of software solutions to analyze omic data and lead to novel insights. Explore informatic solutions capable of scaling to production-level systems such as the NovaSeq X Series to streamline data to insight with efficiency and ease.
Get accurate, comprehensive, and highly efficient bioinformatics with multiple deployment options, applications, and pipelines to meet your research needs.
Integrates with Illumina sequencing systems with an intuitive interface for streamlined run setups and monitoring. Enjoy intuitive push-button secondary analysis and data sharing within a secure cloud ecosystem with expandable storage for growing laboratory needs.
A secure, scalable, bioinformatics platform that enables you to manage, analyze, and interpret large volumes of multiomic data.
Partek Flow bioinformatics software provides a visual user interface, robust statistical algorithms, information-rich visualizations, and cutting-edge genomic tools that enable researchers of all skill levels to confidently perform data analysis.
Read this update on the introduction of innovative pipelines for DRAGEN, including single-cell ATAC-seq and single-cell multiomics (RNA-Seq and ATAC-seq).
Learn how sequencing runs with 10x Genomics libraries can now be directly set up on the Run Planner. The Run Planner tool guides you through the steps needed for preparing your sequencing run, such as specifying sample and index information, read length and analysis options.
Learn how to combine RNA and protein data, statistically assess relationships using correlation between gene and protein molecules, and explore differences between cell types using differential analysis comparisons for biological interpretation.
A secure, scalable, bioinformatics platform that enables you to manage, analyze, and interpret large volumes of multiomic data.
Application note spotlight
Download this Application Note to discover how to simultaneously quantify and spatially map membrane proteins using Molecular Pixelation powered by Illumina NGS. Learn how the ability to measure and visualize 80 surface proteins across 1000 single cells per sample—utilizing the Pixelator pipeline and analysis package—can enhance your understanding of immune cell behavior in cancer.
Your email address is never shared with third parties.
See how you can use multiomics to better connect genotype to phenotype and obtain a full cellular readout not found through single omics approaches.
Your email address is never shared with third parties.
With the NovaSeq X Series, learn how you can perform broader, deeper sequencing and take on omics projects that were previously out of reach.
Your email address is never shared with third parties.
This eBook outlines the NGS analysis workflow and provides an overview of Illumina Connected Software solutions available for analyzing gene expression and regulation data.
Your email address is never shared with third parties.
See how you can use multiomics to better connect genotype to phenotype and obtain a full cellular readout not found through single omics approaches.
In this app note, we compare the performance of the NovaSeq X and NovaSeq 6000 using the TruSight Oncology ctDNA v2 CGP assay. Results demonstrate the same high level of performance with significantly reduced run times when using the NovaSeq X Series.
An interactive omics knowledge base that analyzes private omics data with highly curated public data to help researchers put their data into biological context.
Read how Illumina’s Correlation Engine provides a curated omics knowledge base of biological interactions that is driven by the vast amount of multiomic public data and publications, along with the built-in comprehensive analytic correlation tools.
Read how the 10x Genomics Chromium Single Cell Multiome ATAC + Gene Expression enables simultaneous gene expression profiling and chromatin accessibility from the same cell.
You can learn more at our multiomics page where you’ll see how to expand your research and discovery power across multiple omes.
The NovaSeq X Series is capable of generating large volumes of valuable data which can be analyzed using Illumina Connected Analytics (ICA) for production-scale informatics. ICA provides tight integration with Illumina hardware and software with customizable workflows and built-in security and compliance features to meet regulated environments. In addition, BaseSpace Sequence Hub offers an intuitive interface that allows you to streamline run setups and monitoring using a secure, cloud-based ecosystem suited for growing laboratories.
A variety of solutions are available. Software solutions such as Illumina Connected Analytics and Correlation Engine offer capabilities to analyze microarray and NGS data. Partnered solutions from Partek also offer the ability to analyze NGS, microarray, and qPCR data.
Reach out for information about our products and services, or get answers to questions about our technology.
Your email address is never shared with third parties.