Effortless high-throughput NGS with the NovaSeq X Series
Scale up your way with more speed and flexibility than ever before
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The NovaSeq X Series delivers a reduced cost per Gb, improved operational simplicity, and streamlined bioinformatics. These advances sharply reduce the barriers to sequencing at scale and provide for more samples with the same budget.
Illumina is a trusted technology partner with demonstrated leadership and a proven track record of genomics solutions. We offer industry-leading support and service with instruments you can rely upon.
The NovaSeq X Plus system provides more value and sequencing power in a single system. The dual flow cell capability provides greater flexibility to maximize your throughput as soon as you need it.
The single flow cell NovaSeq X system provides a lower-cost entry point to high-throughput sequencing, powered by XLEAP-SBS. The system is fully compatible with the entire portfolio of sequencing consumables, with the ability to upgrade your system as your needs grow.
Make the move from exomes to genomes with the NovaSeq X Series. It’s easier than ever to expand whole-genome sequencing (WGS) in your lab with the $200 USD genome.* WGS delivers a comprehensive view of the genome, making it ideal for discovery applications.
Boost your efficiency, reduce your turnaround time and labor burden with the two-lane, 1.5B flow cell. It allows you to cost-effectively sample batch and ease into increased throughput for several applications. This flow cell is capable of ~4 human genomes, ~41 exomes, and ~30 transcriptomes per 1.5B flow cell.
* The NovaSeq X Plus System can sequence more than 20,000 whole genomes per year and enables the $200 genome. $200 genome on NovaSeq X Series is delivered at list price on the 25B flow cell.
The decrease in cost/Gb on the NovaSeq X Series reduces the gap between WGS and whole-exome sequencing (WES) by over 2.5× compared to the NovaSeq 6000 System. (Based on US prices for the 25B 300-cycle kit).
Increased discovery power will come from larger studies, deeper sequencing to identify rare genetic events, and broader sequencing methods and multiomics for a more comprehensive view of cellular activity. Learn how the NovaSeq X Series makes it easy to transition to high-throughput and expand your application reach.
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Implementing high-throughput sequencing workflows is faster and easier than ever before with the NovaSeq X Series. There are fewer touch points and steps, from run planning to sequencing and analysis.
You'll spend less time and effort thanks to established, plug-and-play applications for whole-genome sequencing, whole-exome sequencing, and RNA sequencing. Previously a challenging application, human whole-genome sequencing on the NovaSeq X Series is now one of the simplest.
Scaling up has never been easier with a breadth of flow cell options and individually addressable lanes for sample batching and smooth transitioning.
Data quality starts with how accurately a user can interact with an instrument– and this begins with the user experience. Learn how the Illumina Experience Design team took a user-centric approach to the development of the NovaSeq X Series and reagents in this video.
The NovaSeq X Series reagents provide numerous improved efficiencies that support this:
With ambient temperature shipping and lyophilized reagents, high-throughput sequencing is now more accessible around the world. Reduce cold-chain shipping and disposal burdens with elimination of dry ice and ice packs.
* Preliminary results of streamlined Life Cycle Assessment (LCA) conducted by external party regarding climate impact (per Gb of genetic code of NovaSeq X 10B 300-cycle kit compared to NovaSeq 6000 S4 300-cycle kit for the US market, and 41% reduction for UK market (savings are reduced for UK due to replacement of some air freight with truck transport).
Disassembly by pulling the sides and lifting; no tools required
Pinch to release wells allows easy disposal of remaining reagents
Easy to remove labels and RFIDs to recycle Lyo insert, library tube strip, & buffer cartridge
Caps and breather design prevents spills and splashing
You can sequence confidently knowing that over 1000 researchers and clinicians have trusted Illumina and the NovaSeq brand for their high-throughput sequencing needs. With more than two decades of leadership in next-generation sequencing and over 300,000 peer-reviewed publications, Illumina has a proven track record.
Illumina instruments are known for exceptional data quality and reliability. Our comprehensive workflow solutions, from library prep to analysis, and highly robust and validated systems reduce the chance of run failure.
Our best-in-class support includes:
Empower your research using RNA-Seq with the NovaSeq X Series. Learn about the streamlined RNA-to-results workflow that combines power, speed, and flexibility for high-throughput transcriptome analysis in this Application Note.
The Australian Genome Research Facility (AGRF) welcomed Australia’s first NovaSeq X Plus to their lab in Melbourne, Australia.
For the Biomolecular Research Facility at ANU, the NovaSeq X System is going to be essential to sharing data on cell lines and driving that research forward.
The Ramaciotti Centre for Genomics added a NovaSeq X Plus to enable researchers to sequence more samples more cost-effectively.
The system itself is easy to run. The increased stability of the kits at 4C provides more flexibility to change planned runs.
It’s the first system to launch with the XLEAP-SBS, meaning that we’re able to now deliver higher accuracy data compared to the previous generation, faster and at a more affordable cost.
The NovaSeq X Plus will drive innovations in genomics because the cost reduction and throughput enables more researchers to access sequencing and further their research.
The NovaSeq X can do everything and more in half the time with half the file size. It’s going to really improve the quality of work we do and save on time, too.
Talk to an expert about transitioning to high-throughput sequencing in your lab.
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