Illumina technology can advance immunology research by helping elucidate immune cell function and signaling. Immune cells work to protect the body from foreign invaders including viruses, bacteria, and parasites. Mutations and environmental factors can cause the immune system to malfunction and attack the body it is meant to protect. Many immune disorders are classified as complex diseases since they are influenced by both genetics and the environment.
Complex autoimmune disorders include lupus, rheumatoid arthritis, inflammatory bowel disease, and others. The cause and progression of many of these diseases are still poorly understood.
Array and next-generation sequencing (NGS) solutions from Illumina can provide immunology researchers with detailed insight into potential disease mechanisms and the functional consequences of immune-related genetic variation.
AmpliSeq for Illumina Immune Repertoire Plus, TCR beta Panel: Investigate T cell diversity and clonal expansion by sequencing T cell receptor (TCR) beta chain rearrangements.
AmpliSeq for Illumina TCR beta-SR (Short Read) Panel: FFPE-compatible panel for measuring T cell diversity and clonal expansion in tumor samples by sequencing TCR beta chain rearrangements.
AmpliSeq for Illumina Immune Response Panel: Targeted RNA expression panel investigating 395 genes involved in tumor-immune system interactions.
Infinium Immunoarray: Evaluate autoimmune disorder and immune function–associated genetic variants on a single microarray.
NGS can help researchers identify mutations that enable tumors to evade the immune response, as well as neoantigens that can boost T cell-mediated immunity.