Targeted sequencing panel that assesses germline mutations across 113 genes and 125 SNPs associated with genetic cancer risk predisposition.
Assay time
Hands-on time
Input quantity
The TruSight Hereditary Cancer Panel delivers expert-defined content for assessing germline mutations.
Extensive panel includes 113 genes associated with hereditary cancer predisposition
Easy protocol enables fast and flexible library prep and enrichment
Compatibility with all Illumina benchtop sequencing systems with sample throughput ranging from 2 to 256 samples per run
Hybrid–capture enrichment enables good coverage uniformity for accurate detection of SNVs, indels, and CNVs
The panel was developed with input from key opinion leaders and includes 10,341 probes across 113 genes and 125 SNPs.
The panel is used with the Illumina DNA Prep with Enrichment library prep workflow, which takes advantage of enzyme-based DNA fragmentation, removing the instrument cost and need for mechanical fragmentation. Illumina DNA Prep with Enrichment has been qualified with multiple automation systems for a user-friendly workflow.
Indexes available for up to 384 samples allow for flexible batch sizes and scalability across Illumina benchtop sequencing systems.
| Assay time | ~48 hr from DNA to data |
|---|---|
| Automation capability | Liquid handling robot(s) |
| Cancer type | Pan-cancer, Solid tumor |
| Content specifications | Targets 113 cancer risk-associated genes |
| Description | The TruSight Hereditary Cancer Panel is a targeted sequencing panel designed to assess germline mutations across 113 genes and 125 single nucleotide polymorphisms (SNPs) for identification purposes and polygenic risk scoring. |
| Hands-on time | ~2 hr |
| Input quantity | 50–1000 ng DNA |
| Instruments | MiSeq System, iSeq 100 System, NextSeq 550 System, MiniSeq System, NextSeq 550Dx in Research Mode, NextSeq 500 System, MiSeq i100 System, MiSeq i100 Plus System |
| Method | Targeted DNA sequencing, Target enrichment |
| Nucleic acid type | DNA |
| Sample type details | Genomic DNA |
| Specialized sample types | Blood, Saliva |
| Species category | Human |
| Technology | Sequencing |
| Variant class | Germline variants, Insertions-deletions (indels), Copy number variants (CNVs) |
The TruSight Hereditary Cancer Panel workflow requires the TruSight Hereditary Cancer enrichment oligos, Illumina DNA Prep with Enrichment, Illumina DNA/RNA UD indexes, and sequencing reagents.
TruSight Hereditary Cancer Panel is a highly efficient targeted next-generation sequencing (NGS) panel that enables researchers to access an expert-defined content set for analyzing variation within genes previously linked with a predisposition towards cancer.
TruSight Hereditary Cancer – Enrichment Oligos
Illumina DNA Prep with Enrichment
Illumina DNA/RNA UD Indexes
| Instrument | Recommended number of samples | Read length |
|---|---|---|
| iSeq 100 System | Samples per run: 2 (based on 300× mean coverage) |
2 × 150 bp (max recommended) |
| MiniSeq System | Samples per run: mid-output: 5, high-output: 16 (based on 300× mean coverage) |
2 × 150 bp (max recommended) |
| MiSeq System | Samples per run: v2 Micro: 2, v2 Standard: 9, v3 Standard: 16 (based on 300× mean coverage) |
2 × 150 bp (max recommended) |
| NextSeq 500 System | Samples per run: mid-output: 80, high-output: 256 (based on 300× mean coverage) |
2 × 150 bp (max recommended) |
| NextSeq 550 System | Samples per run: mid-output: 80, high-output: 256 (based on 300× mean coverage) |
2 × 150 bp (max recommended) |
Data sheet HTML externalFile
icommunity_articles PDF 4 MB
Technical note PDF 1 MB
Includes 10,341 probes that target 113 genes related to cancer predisposition, recommended in key guidelines, and evaluated on population studies of cases vs. controls.
The TruSight Hereditary Cancer Panel includes an extensive list of genes commonly associated with hereditary predisposition to breast, colon, ovarian, and gastric cancers and recommended in key guidelines.
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The TruSight Hereditary Cancer Panel includes an extensive list of genes commonly associated with hereditary predisposition to breast, colon, ovarian, and gastric cancers.
The TruSight Hereditary Cancer Panel can be run on any benchtop Illumina sequencing system (iSeq 100, MiSeq, MiniSeq, and NextSeq Systems).
TruSight Hereditary Cancer Panel includes 125 SNPs. Of these, 48 are ID SNPs and 77 are used for polygenic risk scoring (PRS).
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