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TruSight Hereditary Cancer Panel

Expert-defined content targeting 113 genes associated with genetic cancer risk predisposition. Read More...
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TruSight Hereditary Cancer – Enrichment Oligos Only (8 Enrichment Reactions)

20029551

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Illumina® DNA Prep with Enrichment, (S) Tagmentation (96 Samples)

20025524

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Illumina® DNA Prep with Enrichment, (S) Tagmentation (16 Samples)

20025523

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Illumina® DNA Prep, (S) Tagmentation (96 Samples)

20025520

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Illumina® DNA Prep, (S) Tagmentation (16 Samples)

20025519

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Index Adapters

IDT® for Illumina® DNA/RNA UD Indexes Set A, Tagmentation (96 Indexes, 96 Samples)

20027213

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IDT® for Illumina® DNA/RNA UD Indexes Set B, Tagmentation (96 Indexes, 96 Samples)

20027214

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IDT® for Illumina Nextera DNA Unique Dual Indexes Set C (96 Indexes, 96 Samples)

20027215

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IDT® for Illumina Nextera DNA Unique Dual Indexes Set D (96 Indexes, 96 Samples)

20027216

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IDT® for Illumina Nextera DNA Unique Dual Indexes Sets A-D (384 Indexes, 384 Samples)

20027217

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Reagents

iSeq 100 i1 Reagent

20021533

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iSeq 100 i1 Reagent 4 pack

20021534

MiSeq Reagent Micro Kit v2 (300-cycles)

MS-103-1002

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MiSeq Reagent Kit v2 (300-cycles)

MS-102-2002

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MiSeq Reagent Kit v3 (600-cycle)

MS-102-3003

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MiniSeq Mid Output Kit (300-cycles)

FC-420-1004

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MiniSeq High Output Reagent Kit (300-cycles)

FC-420-1003

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NextSeq 500/550 Mid Output Kit v2.5 (300 Cycles)

20024905

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NextSeq 500/550 High Output Kit v2.5 (300 Cycles)

20024908

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Accessory Products
What accessories do I need?

Flex Lysis Reagent Kit (96 reactions)

20018706

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TruSight Hereditary Cancer Panel

Product Highlights

The TruSight Hereditary Cancer Panel content was selected based on feedback from key opinion leaders on genetic risk assessment.

  • Includes 10,341 probes that target 113 genes related to cancer predisposition.
  • TruSight Hereditary Cancer Panel includes 125 SNPs. Of these, 48 are ID SNPs and 77 are used for polygenic risk scoring (PRS).
  • In combination with Illumina DNA Prep with Enrichment, TruSight Hereditary Cancer Panel enables genetic labs to prepare hybrid capture sequencing libraries in 6.5 hours with limited hands on time of ~2 hours.
  • Accommodates flexible workflows and is compatible with different sources of samples such as genomic DNA, saliva (Oragene tubes) or blood (Flex Lysis Reagent). It is compatible with all Illumina benchtop sequencers, and allows for maximum flexibility for batching from 2 to 256 samples.

TruSight Hereditary Cancer Panel was created as a modular panel that uses Illumina DNA Prep with Enrichment for library preparation.

Indexes are available for up to 384 samples to allow for flexible batch sizes and scalability across all Illumina benchtop sequencers (iSeq 100, MiSeq, MiniSeq, and NextSeq).

The Illumina DNA Prep with Enrichment library prep workflow uses enzyme-based DNA fragmentation, removing the instrument cost and need for mechanical fragmentation. Illumina DNA Prep with Enrichment has been qualified with multiple automation systems to allow for a user-friendly workflow.

Frequently Purchased Together

Specifications

Product Comparison

TruSight Hereditary Cancer Panel TruSight Cancer AmpliSeq for Illumina BRCA Panel
Assay Time ~6.5 hours 1.5 days 5 hours (library prep only; doesn't include library quantification, normalization, or pooling time)
Content Specifications Targets 113 cancer risk-associated genes Fixed set of probes that enrich for 94 genes and 284 SNPs associated with common and rare cancers. Exonic regions and the flanking intronic sequences of the BRCA1 and BRCA2
Hands-On Time 2 hours 5 hours < 1.5 hours
Input Quantity 50 ng 50 ng DNA 1–100 ng (10 ng recommended per pool)
Mechanism of Action Bead-bound transposomes and hybrid-capture chemistry Multiplex PCR
Method Target Enrichment, Target Enrichment, Targeted DNA Sequencing Target Enrichment, Target Enrichment, Targeted DNA Sequencing Amplicon Sequencing, Targeted DNA Sequencing
Nucleic Acid Type DNA DNA DNA
Technology Sequencing Sequencing Sequencing

Method-Specific Workflow Example

 
Prepare Library with:
Illumina DNA Prep with Enrichment
IDT for Illumina Nextera DNA UD Indexes
 
Sequence Efficiently with:
iSeq 100 System
MiniSeq System
MiSeq System
NextSeq 550 System
 
Analyze Your Data with:
DRAGEN Enrichment
BaseSpace Enrichment
 

Product Literature

Understanding the Polygenicity of Cancer.

icommunity_articles | PDF 4 MB

Data Sheet | HTML | 7 versions

Data Sheet | HTML | 5 versions

Analyze germline CNVs with TruSight Hereditary Cancer Panel

Technical Note | PDF 1 MB

Manuals and Support Information

Custom Protocol Selector
Generates customized, end-to-end instructions

All Illumina DNA Prep with Enrichment  Support  

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Not for use in diagnostic procedures (except as specifically noted).

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